Comparison of Wild Type DNA Sequence of Spike Protein from SARS-CoV-2 with Optimized Sequence on The Induction of Protective Responses Against SARS-Cov-2 Challenge in Mouse Model마우스 모델에서 SARS-CoV-2 공격에 대한 보호 반응 유도에 대한 최적화된 서열과 SARS-CoV-2의 스파이크 단백질 야생형 DNA 서열의 비교Article Published on 2022-12-312022-09-11 Journal: Human vaccines & immunotherapeutics [Category] COVID19(2023년), SARS, 비임상, 진단, [키워드] acid Against Antiviral binding breath CD4 CD8+ cellular immune responses cellular immunity challenge clinical trial contributing to COVID-19 CTL demonstrated DNA DNA vaccine expression full-length spike protein hACE2 humoral humoral and cellular immunity IFN-γ immune immune responses immunogen in vitro induction mice Model mouse Neutralizing antibodies optimization optimizations pGX-9501 platform Protective Protective effects protective response RBD binding response robust SARS-CoV-2 sequence spike Spike protein subsequent T cell T cells the vaccine Transgenic mouse Type virus wild-type wild-type sequence. [DOI] 10.1080/21645515.2021.2016201 PMC 바로가기 [Article Type] Article
Buildout and integration of an automated high-throughput CLIA laboratory for SARS-CoV-2 testing on a large urban campusArticle Published on 2022-10-012022-11-15 Journal: Slas Technology [Category] COVID19(2023년), SARS, 치료기술, [키워드] addition automated Boston changed CLIA clinical clinical testing costly COVID-19 COVID-19 testing CTL equipment increase in Laboratory lifted mitigate Outbreaks pandemic performed Personal protective equipment Precaution protocol reverse transcription PCR RT-qPCR Safe SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 PCR test SARS-CoV-2 testing Testing The United States university Wuhan, China [DOI] 10.1016/j.slast.2022.06.003 PMC 바로가기
The potential of developing a protective peptide-based vaccines against SARS-CoV-2Article Published on 2022-09-012022-11-15 Journal: Drug development research [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] antigens approved B-cell cellular COVID-19 COVID-19 vaccine CTL effective Efficacy Genetic genetic material genetic vaccines host cell humoral humoral immune response infectious disease outbreak investigated kill less lineages neutralize Neutralizing antibodies occur opsonize overcome pandemic peptide peptide epitope peptide vaccine Peptide vaccines peptide-based vaccine Protective Protein Reinfection Replication response Safe Safety. SARS-CoV-2 SARS-CoV-2-specific antibody Spanish flu T-cell Vaccine Vaccines variant virus [DOI] 10.1002/ddr.21969 PMC 바로가기
A single immunization with cellular vaccine confers dual protection against SARS-CoV-2 and cancer세포 백신을 사용한 단일 면역은 SARS-CoV-2 및 암에 대한 이중 보호를 제공합니다Article Published on 2022-08-012022-09-12 Journal: Cancer science [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] acute respiratory syndrome adaptive addition anti-SARS-CoV-2 Antigen applied Cancer Cancer patients CD4 Cell cellular complex coronavirus coronavirus disease COVID-19 CTL CTLs cytotoxic Cytotoxic T cells Effect Effectiveness Efficacy elicited evaluated Evidence Express immune response immunization immunized mice Immunocompromised Innate immunity lung parenchyma memory T cells multifunctional murine model natural killer natural killer T cells SARS-CoV-2 single dose Spike protein T-cell Therapies therapy this system Vaccine vaccine candidate vaccine platform vaccine. [DOI] 10.1111/cas.15434 PMC 바로가기 [Article Type] Article
Applying high throughput and comprehensive immunoinformatics approaches to design a trivalent subunit vaccine for induction of immune response against emerging human coronaviruses SARS-CoV, MERS-CoV and SARS-CoV-2새로운 인간 코로나바이러스 SARS-CoV, MERS-CoV 및 SARS-CoV-2에 대한 면역 반응 유도를 위한 3가 서브유닛 백신을 설계하기 위해 높은 처리량 및 포괄적인 면역정보학 접근법 적용Article Published on 2022-08-012022-09-11 Journal: Journal of biomolecular structure & dynamics [Category] SARS, 치료법, [키워드] acute respiratory syndrome added adjuvant against SARS-CoV analysis Antigen antigens applied Applying approach approach B-cell binding affinity codon optimization complex conducted coronavirus disease Coronavirus disease 2019 CoV COVID-19 CoVs CTL defensin demonstrated disease docking epitope Epitopes facilitate HLA HTL HTLs human coronavirus IEDB IFN IFN-γ immune response immune responses immunogenic immunoinformatics In silico cloning increased expression kDa MDs membrane MERS MERS-CoV MERS‐CoV MHC I Middle East Middle East respiratory syndrome molecular dynamics Molecular dynamics simulation molecular weight molecule Multi-epitope vaccine non-allergenic non-structural protein nucleocapsid PADRE Pan predicted Protein responses SARS-CoV SARS-CoV-2 SARS‐CoV secondary selected epitope sequence sequences Severe acute respiratory syndrome stability stimulate Structure subunit Subunit vaccine Subunit vaccine. syndrome T lymphocyte TAT the vaccine trivalent Vaccine was used β-defensin [DOI] 10.1080/07391102.2021.1876774 PMC 바로가기 [Article Type] Article
Coronavirus disease 2019 and the placenta: A literature review코로나바이러스 질병 2019 및 태반: 문헌 검토Review Published on 2022-08-012022-09-11 Journal: Placenta [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료기술, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme-2 Antigen Basigin canonical cathepsin B Cathepsin B/L caused CD147 CD26 Chain Reaction Clinical pathology coding coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 CTL dipeptidyl peptidase Dipeptidyl peptidase-4 DPP4 electron microscopy eligible enzyme evaluate Express expressed Factor fetal furin IFITM1 immunohistochemistry implicated In situ hybridization interferon involved literature review Localization LY6E lymphocyte mechanism Microscopy multiple organ multiple organs nonspecific organ systems Particle Particles Pathogenesis pathogenesis of SARS-CoV-2 pathology permissiveness Placenta placental Placental infection placental pathology polymerase chain polymerase chain reaction Pregnancy pregnancy trimesters profile Proteases Protein Proteins receptor reduce RNA SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 receptors Serine severe acute respiratory syndrome Coronavirus single-cell analysis single-cell analysis. the disease TMPRSS2 transmembrane transmembrane protein transmembrane serine protease Vascular viral pathogenesis Viral RNA virus [DOI] 10.1016/j.placenta.2022.07.007 PMC 바로가기 [Article Type] Review
SARS-CoV-2-Specific and Functional Cytotoxic CD8 Cells in Primary Antibody Deficiency: Natural Infection and Response to Vaccine1차 항체 결핍에서 SARS-CoV-2-특이적 및 기능적 세포독성 CD8 세포: 자연 감염 및 백신에 대한 반응Article Published on 2022-07-012022-09-12 Journal: Journal of Clinical Immunology [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] analyzed CD107a CD8 CD8 T cell clearance Control COVID-19 COVID-19 infection COVID-19 mRNA Vaccination COVID-19 vaccine COVID19 Critical CTL CTLs CVID cytotoxic Cytotoxic T cell deficiency dose evaluated examined flow cytometry functional granzyme B healthy healthy control immunodeficiency infected cells Infection isotype control monoclonal antibody mRNA vaccine natural natural infection Patient patients with CVID Pfizer-BioNTech Pfizer/BNT vaccine primary antibody reduced reported response responses robust SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike SARS-CoV-2-specific CD8 T cells significantly lower subject T cell response the patient vaccination were stained X-linked agammaglobulinemia XLA XLA. [DOI] 10.1007/s10875-022-01256-y PMC 바로가기 [Article Type] Article
T Cells in Multisystem Inflammatory Syndrome in Children (MIS-C) Have a Predominant CD4+ T Helper Response to SARS-CoV-2 Peptides and Numerous Virus-Specific CD4- CD8- Double-Negative T Cells소아 다기관 염증 증후군(MIS-C)의 T 세포는 SARS-CoV-2 펩티드 및 수많은 바이러스 특이적 CD4-CD8- 이중 음성 T 세포에 대한 CD4+ T 도우미 반응이 우세합니다.Article Published on 2022-06-292022-09-11 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 치료기술, [키워드] Activation Antigen CD3+ CD4 CD4+ CD4− CD8− double-negative T cells CD8 CD8+ CD8+ T cell CD8+ T cells children classical CTL Cytotoxic T cell enrolled epitope Epitopes example Follow-up frequencies helper immunodominant epitopes initial IQR lymphopenia magnitude majority MIS-C Numerous pathogenic Patient peptide peptide pool peptide pools peptides physiological response Protein Proteins Recognition recognize reported response SARS-CoV-2 SARS-CoV-2 peptide SARS-CoV-2 peptides SARS-CoV-2 spike SARS-CoV-2-specific T cell SARS-CoV-2-specific T cells single subject subject subjects subpopulation T cell T cell receptor T cell receptor Vβ21.3 T cell response T cell responses T cells T cells. T helper TCRs virus [DOI] 10.3390/ijms23137219 PMC 바로가기 [Article Type] Article
Subtractive proteomics assisted therapeutic targets mining and designing ensemble vaccine against Candida auris for immune response induction감산 단백질체학 보조 치료 표적 마이닝 및 면역 반응 유도를 위한 Candida auris에 대한 앙상블 백신 설계Article Published on 2022-06-012022-09-11 Journal: Computers in biology and medicine [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] antigenic approach approach B cell Candida Candida auris candidate caused characterization Co-infection COVID-19 COVID-19 patient CTL demonstrated effective effective therapy Efficacy feature global pandemic HTL IgG IgM IL-6 immune immune response Immune simulation immunogenic peptide in-silico Infection infections interferon Interferon-α molecular docking Multi-epitope vaccine non-allergenic peptides producing proteome proteomics provide SARS-CoV-2 Seven Subtractive proteomics target targets the vaccine therapeutic target therapeutic targets threshold Vaccine vaccine candidate vaccine candidates Vaccines. validation variant variants was performed [DOI] 10.1016/j.compbiomed.2022.105462 PMC 바로가기 [Article Type] Article
Markers of Memory CD8 T Cells Depicting the Effect of the BNT162b2 mRNA COVID-19 Vaccine in Japan일본에서 BNT162b2 mRNA COVID-19 백신의 효과를 나타내는 메모리 CD8 T 세포의 마커Article Published on 2022-04-282022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 치료기술, [키워드] Affect anti-S antibody Antibody titers Antigen BNT162b2 BNT162b2 mRNA BNT162b2 vaccine boost CD107a CD38 CD8 CD8, vaccine CD8+ cell CD8+ cells CD8+ T cell CD8+ T cells Cell Cellular immune response cellular immune responses cellular immunity COVID-19 CTL Effect effector cell effector cells Efficacy elicit elicited environmental factor evaluate expression female Frequency function functions Genetic granzyme B immune responses intensity investigated Japan Japanese KLRG1 male males marker markers. memory memory CD8+ T cells mRNA vaccination nucleoside nucleoside-modified mRNA pentamer positive cells positively correlated precursor proliferation Protein provide response S protein SARS-CoV-2 spike glycoprotein second vaccination serum Sex difference spike glycoprotein T cell T cell proliferation T cells Vaccine was increased [DOI] 10.3389/fimmu.2022.836923 PMC 바로가기 [Article Type] Article